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302 The progression of insulin resistance in diabetes contributes to widespread metabolic abnormalities, leading to a spectrum of detrimental complications, including microvascular injury, diabetic cardiomyopathy, retinopathy, diabetic nephropathy, and susceptibility to infectious diseases

Second, ROS and mitochondrial DNA (mtDNA), as damage-associated molecular patterns (DAMPs), along with pathogen-associated molecular patterns (PAMPs), may activate the NLRP3 inflammasome and induce the release of pro-inflammatory cytokines such as IL-1, IL-6, and TNF-, potentially transforming localized metabolic stress into a systemic inflammatory response

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Mengesha has been instrumental in promoting STEM education nationally, serving as Chair of the E-STEM Education Council and the Dessie Branch of the Ethiopian Space Science Society

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Silencing ACSL4 in the substantia nigra can prevent dopaminergic neuron death and motor defects in PD mice, and inhibition of ACSL4 activity with triacsin C can improve the PD phenotype